Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials.
Identifieur interne : 003203 ( Main/Exploration ); précédent : 003202; suivant : 003204Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials.
Auteurs : James Chih-Hsin Yang [Taïwan] ; Yi-Long Wu [République populaire de Chine] ; Martin Schuler [Allemagne] ; Martin Sebastian [Allemagne] ; Sanjay Popat [Royaume-Uni] ; Nobuyuki Yamamoto [Japon] ; Caicun Zhou [République populaire de Chine] ; Cheng-Ping Hu [République populaire de Chine] ; Kenneth O'Byrne [Australie] ; Jifeng Feng [République populaire de Chine] ; Shun Lu [République populaire de Chine] ; Yunchao Huang [République populaire de Chine] ; Sarayut L. Geater [Thaïlande] ; Kye Young Lee [Corée du Sud] ; Chun-Ming Tsai [Taïwan] ; Vera Gorbunova [Russie] ; Vera Hirsh [Canada] ; Jaafar Bennouna [France] ; Sergey Orlov [Russie] ; Tony Mok [République populaire de Chine] ; Michael Boyer [Australie] ; Wu-Chou Su [Taïwan] ; Ki Hyeong Lee [Corée du Sud] ; Terufumi Kato [Japon] ; Dan Massey [Royaume-Uni] ; Mehdi Shahidi [Royaume-Uni] ; Victoria Zazulina [Royaume-Uni] ; Lecia V. Sequist [États-Unis]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Adénocarcinome (anatomopathologie), Adénocarcinome (génétique), Adénocarcinome (mortalité), Adénocarcinome (traitement médicamenteux), Cisplatine (administration et posologie), Désoxycytidine (administration et posologie), Désoxycytidine (analogues et dérivés), Femelle, Glutamates (administration et posologie), Guanine (administration et posologie), Guanine (analogues et dérivés), Humains, Mutation (génétique), Mâle, Pronostic, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Pémétrexed, Quinazolines (usage thérapeutique), Récepteur du facteur de croissance épidermique (antagonistes et inhibiteurs), Récepteur du facteur de croissance épidermique (génétique), Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (génétique), Tumeurs du poumon (mortalité), Tumeurs du poumon (traitement médicamenteux), Études de suivi.
- MESH :
- administration et posologie : Cisplatine, Désoxycytidine, Glutamates, Guanine.
- analogues et dérivés : Désoxycytidine, Guanine.
- anatomopathologie : Adénocarcinome, Tumeurs du poumon.
- antagonistes et inhibiteurs : Récepteur du facteur de croissance épidermique.
- génétique : Adénocarcinome, Mutation, Récepteur du facteur de croissance épidermique, Tumeurs du poumon.
- mortalité : Adénocarcinome, Tumeurs du poumon.
- traitement médicamenteux : Adénocarcinome, Tumeurs du poumon.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique, Quinazolines.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Pronostic, Pémétrexed, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Études de suivi.
English descriptors
- KwdEn :
- Adenocarcinoma (drug therapy), Adenocarcinoma (genetics), Adenocarcinoma (mortality), Adenocarcinoma (pathology), Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Cisplatin (administration & dosage), Deoxycytidine (administration & dosage), Deoxycytidine (analogs & derivatives), Female, Follow-Up Studies, Glutamates (administration & dosage), Guanine (administration & dosage), Guanine (analogs & derivatives), Humans, Lung Neoplasms (drug therapy), Lung Neoplasms (genetics), Lung Neoplasms (mortality), Lung Neoplasms (pathology), Male, Middle Aged, Mutation (genetics), Neoplasm Staging, Pemetrexed, Prognosis, Quinazolines (therapeutic use), Receptor, Epidermal Growth Factor (antagonists & inhibitors), Receptor, Epidermal Growth Factor (genetics), Survival Rate.
- MESH :
- chemical , administration & dosage : Cisplatin, Deoxycytidine, Glutamates, Guanine.
- chemical , analogs & derivatives : Deoxycytidine, Guanine.
- chemical , antagonists & inhibitors : Receptor, Epidermal Growth Factor.
- drug therapy : Adenocarcinoma, Lung Neoplasms.
- genetics : Adenocarcinoma, Lung Neoplasms, Mutation, Receptor, Epidermal Growth Factor.
- mortality : Adenocarcinoma, Lung Neoplasms.
- pathology : Adenocarcinoma, Lung Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols, Quinazolines.
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Pemetrexed, Prognosis, Survival Rate.
Abstract
We aimed to assess the effect of afatinib on overall survival of patients with EGFR mutation-positive lung adenocarcinoma through an analysis of data from two open-label, randomised, phase 3 trials.
DOI: 10.1016/S1470-2045(14)71173-8
PubMed: 25589191
Affiliations:
- Allemagne, Australie, Canada, Corée du Sud, France, Japon, Royaume-Uni, Russie, République populaire de Chine, Taïwan, Thaïlande, États-Unis
- Angleterre, District fédéral central, Grand Londres, Guangdong, Massachusetts, Pays de la Loire, Québec, Rhénanie-Palatinat, Région capitale de Séoul
- Jiangmen, Londres, Mayence, Montréal, Moscou, Nantes, Sha Tin, Séoul
- Université McGill, Université chinoise de Hong Kong
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Le document en format XML
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Electronic address: chihyang@ntu.edu.tw.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Taiwan University Hospital and National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Yi Long" sort="Wu, Yi Long" uniqKey="Wu Y" first="Yi-Long" last="Wu">Yi-Long Wu</name><affiliation wicri:level="3"><nlm:affiliation>Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Schuler, Martin" sort="Schuler, Martin" uniqKey="Schuler M" first="Martin" last="Schuler">Martin Schuler</name><affiliation wicri:level="1"><nlm:affiliation>West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Sebastian, Martin" sort="Sebastian, Martin" uniqKey="Sebastian M" first="Martin" last="Sebastian">Martin Sebastian</name><affiliation wicri:level="3"><nlm:affiliation>Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, and University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, and University Medical Center of the Johannes Gutenberg University Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Popat, Sanjay" sort="Popat, Sanjay" uniqKey="Popat S" first="Sanjay" last="Popat">Sanjay Popat</name><affiliation wicri:level="3"><nlm:affiliation>Royal Marsden Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Yamamoto, Nobuyuki" sort="Yamamoto, Nobuyuki" uniqKey="Yamamoto N" first="Nobuyuki" last="Yamamoto">Nobuyuki Yamamoto</name><affiliation wicri:level="1"><nlm:affiliation>Wakayama Medical University, Wakayama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Wakayama Medical University, Wakayama</wicri:regionArea><wicri:noRegion>Wakayama</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Caicun" sort="Zhou, Caicun" uniqKey="Zhou C" first="Caicun" last="Zhou">Caicun Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Pulmonary Hospital, Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Cheng Ping" sort="Hu, Cheng Ping" uniqKey="Hu C" first="Cheng-Ping" last="Hu">Cheng-Ping Hu</name><affiliation wicri:level="1"><nlm:affiliation>Xiangya Hospital, Central South University, Changsha, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangya Hospital, Central South University, Changsha</wicri:regionArea><wicri:noRegion>Changsha</wicri:noRegion></affiliation></author><author><name sortKey="O Byrne, Kenneth" sort="O Byrne, Kenneth" uniqKey="O Byrne K" first="Kenneth" last="O'Byrne">Kenneth O'Byrne</name><affiliation wicri:level="1"><nlm:affiliation>Princess Alexandra Hospital and Queensland University of Technology, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Princess Alexandra Hospital and Queensland University of Technology</wicri:regionArea></affiliation></author><author><name sortKey="Feng, Jifeng" sort="Feng, Jifeng" uniqKey="Feng J" first="Jifeng" last="Feng">Jifeng Feng</name><affiliation wicri:level="1"><nlm:affiliation>Jiangsu Province Cancer Hospital, Nanjing, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Province Cancer Hospital, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Shun" sort="Lu, Shun" uniqKey="Lu S" first="Shun" last="Lu">Shun Lu</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yunchao" sort="Huang, Yunchao" uniqKey="Huang Y" first="Yunchao" last="Huang">Yunchao Huang</name><affiliation wicri:level="1"><nlm:affiliation>Yunnan Tumor Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, Yunnan Province, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Yunnan Tumor Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, Yunnan Province</wicri:regionArea><wicri:noRegion>Yunnan Province</wicri:noRegion></affiliation></author><author><name sortKey="Geater, Sarayut L" sort="Geater, Sarayut L" uniqKey="Geater S" first="Sarayut L" last="Geater">Sarayut L. Geater</name><affiliation wicri:level="1"><nlm:affiliation>Prince of Songkla University, Songkhla, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Prince of Songkla University, Songkhla</wicri:regionArea><wicri:noRegion>Songkhla</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Kye Young" sort="Lee, Kye Young" uniqKey="Lee K" first="Kye Young" last="Lee">Kye Young Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Konkuk University Medical Center, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Konkuk University Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Tsai, Chun Ming" sort="Tsai, Chun Ming" uniqKey="Tsai C" first="Chun-Ming" last="Tsai">Chun-Ming Tsai</name><affiliation wicri:level="1"><nlm:affiliation>Taipei Veterans General Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei Veterans General Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Gorbunova, Vera" sort="Gorbunova, Vera" uniqKey="Gorbunova V" first="Vera" last="Gorbunova">Vera Gorbunova</name><affiliation wicri:level="3"><nlm:affiliation>FSBI "N N Blokhin Russian Cancer Research Centre", Russian Academy of Medical Sciences, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>FSBI "N N Blokhin Russian Cancer Research Centre", Russian Academy of Medical Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Hirsh, Vera" sort="Hirsh, Vera" uniqKey="Hirsh V" first="Vera" last="Hirsh">Vera Hirsh</name><affiliation wicri:level="4"><nlm:affiliation>McGill University, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Bennouna, Jaafar" sort="Bennouna, Jaafar" uniqKey="Bennouna J" first="Jaafar" last="Bennouna">Jaafar Bennouna</name><affiliation wicri:level="3"><nlm:affiliation>Institut de Cancérologie de l'Ouest-site René Gauducheau, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cancérologie de l'Ouest-site René Gauducheau, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Orlov, Sergey" sort="Orlov, Sergey" uniqKey="Orlov S" first="Sergey" last="Orlov">Sergey Orlov</name><affiliation wicri:level="1"><nlm:affiliation>Pavlov State Medical University, St Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Pavlov State Medical University, St Petersburg</wicri:regionArea><wicri:noRegion>St Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Mok, Tony" sort="Mok, Tony" uniqKey="Mok T" first="Tony" last="Mok">Tony Mok</name><affiliation wicri:level="4"><nlm:affiliation>State Key Laboratory of South China, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of South China, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Boyer, Michael" sort="Boyer, Michael" uniqKey="Boyer M" first="Michael" last="Boyer">Michael Boyer</name><affiliation wicri:level="1"><nlm:affiliation>Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Prince Alfred Hospital, Camperdown, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Su, Wu Chou" sort="Su, Wu Chou" uniqKey="Su W" first="Wu-Chou" last="Su">Wu-Chou Su</name><affiliation wicri:level="1"><nlm:affiliation>National Cheng Kung University Hospital, Tainan, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Cheng Kung University Hospital, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Ki Hyeong" sort="Lee, Ki Hyeong" uniqKey="Lee K" first="Ki Hyeong" last="Lee">Ki Hyeong Lee</name><affiliation wicri:level="1"><nlm:affiliation>Chungbuk National University Hospital, Cheongju, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Chungbuk National University Hospital, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Kato, Terufumi" sort="Kato, Terufumi" uniqKey="Kato T" first="Terufumi" last="Kato">Terufumi Kato</name><affiliation wicri:level="1"><nlm:affiliation>Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Kanagawa Cardiovascular and Respiratory Center, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Massey, Dan" sort="Massey, Dan" uniqKey="Massey D" first="Dan" last="Massey">Dan Massey</name><affiliation wicri:level="1"><nlm:affiliation>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire</wicri:regionArea><wicri:noRegion>Berkshire</wicri:noRegion></affiliation></author><author><name sortKey="Shahidi, Mehdi" sort="Shahidi, Mehdi" uniqKey="Shahidi M" first="Mehdi" last="Shahidi">Mehdi Shahidi</name><affiliation wicri:level="1"><nlm:affiliation>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire</wicri:regionArea><wicri:noRegion>Berkshire</wicri:noRegion></affiliation></author><author><name sortKey="Zazulina, Victoria" sort="Zazulina, Victoria" uniqKey="Zazulina V" first="Victoria" last="Zazulina">Victoria Zazulina</name><affiliation wicri:level="1"><nlm:affiliation>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire</wicri:regionArea><wicri:noRegion>Berkshire</wicri:noRegion></affiliation></author><author><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. Sequist</name><affiliation wicri:level="2"><nlm:affiliation>Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25589191</idno><idno type="pmid">25589191</idno><idno type="doi">10.1016/S1470-2045(14)71173-8</idno><idno type="wicri:Area/PubMed/Corpus">003011</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003011</idno><idno type="wicri:Area/PubMed/Curation">002F30</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002F30</idno><idno type="wicri:Area/PubMed/Checkpoint">002F30</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002F30</idno><idno type="wicri:Area/Ncbi/Merge">002166</idno><idno type="wicri:Area/Ncbi/Curation">002166</idno><idno type="wicri:Area/Ncbi/Checkpoint">002166</idno><idno type="wicri:Area/Main/Merge">003204</idno><idno type="wicri:Area/Main/Curation">003203</idno><idno type="wicri:Area/Main/Exploration">003203</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials.</title><author><name sortKey="Yang, James Chih Hsin" sort="Yang, James Chih Hsin" uniqKey="Yang J" first="James Chih-Hsin" last="Yang">James Chih-Hsin Yang</name><affiliation wicri:level="1"><nlm:affiliation>National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan. Electronic address: chihyang@ntu.edu.tw.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Taiwan University Hospital and National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Yi Long" sort="Wu, Yi Long" uniqKey="Wu Y" first="Yi-Long" last="Wu">Yi-Long Wu</name><affiliation wicri:level="3"><nlm:affiliation>Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Schuler, Martin" sort="Schuler, Martin" uniqKey="Schuler M" first="Martin" last="Schuler">Martin Schuler</name><affiliation wicri:level="1"><nlm:affiliation>West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Sebastian, Martin" sort="Sebastian, Martin" uniqKey="Sebastian M" first="Martin" last="Sebastian">Martin Sebastian</name><affiliation wicri:level="3"><nlm:affiliation>Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, and University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, and University Medical Center of the Johannes Gutenberg University Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Popat, Sanjay" sort="Popat, Sanjay" uniqKey="Popat S" first="Sanjay" last="Popat">Sanjay Popat</name><affiliation wicri:level="3"><nlm:affiliation>Royal Marsden Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Yamamoto, Nobuyuki" sort="Yamamoto, Nobuyuki" uniqKey="Yamamoto N" first="Nobuyuki" last="Yamamoto">Nobuyuki Yamamoto</name><affiliation wicri:level="1"><nlm:affiliation>Wakayama Medical University, Wakayama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Wakayama Medical University, Wakayama</wicri:regionArea><wicri:noRegion>Wakayama</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Caicun" sort="Zhou, Caicun" uniqKey="Zhou C" first="Caicun" last="Zhou">Caicun Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Pulmonary Hospital, Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Cheng Ping" sort="Hu, Cheng Ping" uniqKey="Hu C" first="Cheng-Ping" last="Hu">Cheng-Ping Hu</name><affiliation wicri:level="1"><nlm:affiliation>Xiangya Hospital, Central South University, Changsha, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangya Hospital, Central South University, Changsha</wicri:regionArea><wicri:noRegion>Changsha</wicri:noRegion></affiliation></author><author><name sortKey="O Byrne, Kenneth" sort="O Byrne, Kenneth" uniqKey="O Byrne K" first="Kenneth" last="O'Byrne">Kenneth O'Byrne</name><affiliation wicri:level="1"><nlm:affiliation>Princess Alexandra Hospital and Queensland University of Technology, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Princess Alexandra Hospital and Queensland University of Technology</wicri:regionArea></affiliation></author><author><name sortKey="Feng, Jifeng" sort="Feng, Jifeng" uniqKey="Feng J" first="Jifeng" last="Feng">Jifeng Feng</name><affiliation wicri:level="1"><nlm:affiliation>Jiangsu Province Cancer Hospital, Nanjing, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Province Cancer Hospital, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Shun" sort="Lu, Shun" uniqKey="Lu S" first="Shun" last="Lu">Shun Lu</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yunchao" sort="Huang, Yunchao" uniqKey="Huang Y" first="Yunchao" last="Huang">Yunchao Huang</name><affiliation wicri:level="1"><nlm:affiliation>Yunnan Tumor Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, Yunnan Province, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Yunnan Tumor Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, Yunnan Province</wicri:regionArea><wicri:noRegion>Yunnan Province</wicri:noRegion></affiliation></author><author><name sortKey="Geater, Sarayut L" sort="Geater, Sarayut L" uniqKey="Geater S" first="Sarayut L" last="Geater">Sarayut L. Geater</name><affiliation wicri:level="1"><nlm:affiliation>Prince of Songkla University, Songkhla, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Prince of Songkla University, Songkhla</wicri:regionArea><wicri:noRegion>Songkhla</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Kye Young" sort="Lee, Kye Young" uniqKey="Lee K" first="Kye Young" last="Lee">Kye Young Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Konkuk University Medical Center, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Konkuk University Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Tsai, Chun Ming" sort="Tsai, Chun Ming" uniqKey="Tsai C" first="Chun-Ming" last="Tsai">Chun-Ming Tsai</name><affiliation wicri:level="1"><nlm:affiliation>Taipei Veterans General Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei Veterans General Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Gorbunova, Vera" sort="Gorbunova, Vera" uniqKey="Gorbunova V" first="Vera" last="Gorbunova">Vera Gorbunova</name><affiliation wicri:level="3"><nlm:affiliation>FSBI "N N Blokhin Russian Cancer Research Centre", Russian Academy of Medical Sciences, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>FSBI "N N Blokhin Russian Cancer Research Centre", Russian Academy of Medical Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Hirsh, Vera" sort="Hirsh, Vera" uniqKey="Hirsh V" first="Vera" last="Hirsh">Vera Hirsh</name><affiliation wicri:level="4"><nlm:affiliation>McGill University, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Bennouna, Jaafar" sort="Bennouna, Jaafar" uniqKey="Bennouna J" first="Jaafar" last="Bennouna">Jaafar Bennouna</name><affiliation wicri:level="3"><nlm:affiliation>Institut de Cancérologie de l'Ouest-site René Gauducheau, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cancérologie de l'Ouest-site René Gauducheau, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Orlov, Sergey" sort="Orlov, Sergey" uniqKey="Orlov S" first="Sergey" last="Orlov">Sergey Orlov</name><affiliation wicri:level="1"><nlm:affiliation>Pavlov State Medical University, St Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Pavlov State Medical University, St Petersburg</wicri:regionArea><wicri:noRegion>St Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Mok, Tony" sort="Mok, Tony" uniqKey="Mok T" first="Tony" last="Mok">Tony Mok</name><affiliation wicri:level="4"><nlm:affiliation>State Key Laboratory of South China, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of South China, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Boyer, Michael" sort="Boyer, Michael" uniqKey="Boyer M" first="Michael" last="Boyer">Michael Boyer</name><affiliation wicri:level="1"><nlm:affiliation>Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Prince Alfred Hospital, Camperdown, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Su, Wu Chou" sort="Su, Wu Chou" uniqKey="Su W" first="Wu-Chou" last="Su">Wu-Chou Su</name><affiliation wicri:level="1"><nlm:affiliation>National Cheng Kung University Hospital, Tainan, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Cheng Kung University Hospital, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Ki Hyeong" sort="Lee, Ki Hyeong" uniqKey="Lee K" first="Ki Hyeong" last="Lee">Ki Hyeong Lee</name><affiliation wicri:level="1"><nlm:affiliation>Chungbuk National University Hospital, Cheongju, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Chungbuk National University Hospital, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Kato, Terufumi" sort="Kato, Terufumi" uniqKey="Kato T" first="Terufumi" last="Kato">Terufumi Kato</name><affiliation wicri:level="1"><nlm:affiliation>Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Kanagawa Cardiovascular and Respiratory Center, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Massey, Dan" sort="Massey, Dan" uniqKey="Massey D" first="Dan" last="Massey">Dan Massey</name><affiliation wicri:level="1"><nlm:affiliation>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire</wicri:regionArea><wicri:noRegion>Berkshire</wicri:noRegion></affiliation></author><author><name sortKey="Shahidi, Mehdi" sort="Shahidi, Mehdi" uniqKey="Shahidi M" first="Mehdi" last="Shahidi">Mehdi Shahidi</name><affiliation wicri:level="1"><nlm:affiliation>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire</wicri:regionArea><wicri:noRegion>Berkshire</wicri:noRegion></affiliation></author><author><name sortKey="Zazulina, Victoria" sort="Zazulina, Victoria" uniqKey="Zazulina V" first="Victoria" last="Zazulina">Victoria Zazulina</name><affiliation wicri:level="1"><nlm:affiliation>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Boehringer Ingelheim Ltd UK, Bracknell, Berkshire</wicri:regionArea><wicri:noRegion>Berkshire</wicri:noRegion></affiliation></author><author><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. Sequist</name><affiliation wicri:level="2"><nlm:affiliation>Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (drug therapy)</term><term>Adenocarcinoma (genetics)</term><term>Adenocarcinoma (mortality)</term><term>Adenocarcinoma (pathology)</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Cisplatin (administration & dosage)</term><term>Deoxycytidine (administration & dosage)</term><term>Deoxycytidine (analogs & derivatives)</term><term>Female</term><term>Follow-Up Studies</term><term>Glutamates (administration & dosage)</term><term>Guanine (administration & dosage)</term><term>Guanine (analogs & derivatives)</term><term>Humans</term><term>Lung Neoplasms (drug therapy)</term><term>Lung Neoplasms (genetics)</term><term>Lung Neoplasms (mortality)</term><term>Lung Neoplasms (pathology)</term><term>Male</term><term>Middle Aged</term><term>Mutation (genetics)</term><term>Neoplasm Staging</term><term>Pemetrexed</term><term>Prognosis</term><term>Quinazolines (therapeutic use)</term><term>Receptor, Epidermal Growth Factor (antagonists & inhibitors)</term><term>Receptor, Epidermal Growth Factor (genetics)</term><term>Survival Rate</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Adénocarcinome (anatomopathologie)</term><term>Adénocarcinome (génétique)</term><term>Adénocarcinome (mortalité)</term><term>Adénocarcinome (traitement médicamenteux)</term><term>Cisplatine (administration et posologie)</term><term>Désoxycytidine (administration et posologie)</term><term>Désoxycytidine (analogues et dérivés)</term><term>Femelle</term><term>Glutamates (administration et posologie)</term><term>Guanine (administration et posologie)</term><term>Guanine (analogues et dérivés)</term><term>Humains</term><term>Mutation (génétique)</term><term>Mâle</term><term>Pronostic</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Pémétrexed</term><term>Quinazolines (usage thérapeutique)</term><term>Récepteur du facteur de croissance épidermique (antagonistes et inhibiteurs)</term><term>Récepteur du facteur de croissance épidermique (génétique)</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (génétique)</term><term>Tumeurs du poumon (mortalité)</term><term>Tumeurs du poumon (traitement médicamenteux)</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cisplatin</term><term>Deoxycytidine</term><term>Glutamates</term><term>Guanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Deoxycytidine</term><term>Guanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Receptor, Epidermal Growth Factor</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Cisplatine</term><term>Désoxycytidine</term><term>Glutamates</term><term>Guanine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Désoxycytidine</term><term>Guanine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Récepteur du facteur de croissance épidermique</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Adenocarcinoma</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma</term><term>Lung Neoplasms</term><term>Mutation</term><term>Receptor, Epidermal Growth Factor</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénocarcinome</term><term>Mutation</term><term>Récepteur du facteur de croissance épidermique</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Adenocarcinoma</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adenocarcinoma</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term><term>Quinazolines</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term><term>Quinazolines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Pemetrexed</term><term>Prognosis</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pronostic</term><term>Pémétrexed</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to assess the effect of afatinib on overall survival of patients with EGFR mutation-positive lung adenocarcinoma through an analysis of data from two open-label, randomised, phase 3 trials.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Corée du Sud</li><li>France</li><li>Japon</li><li>Royaume-Uni</li><li>Russie</li><li>République populaire de Chine</li><li>Taïwan</li><li>Thaïlande</li><li>États-Unis</li></country><region><li>Angleterre</li><li>District fédéral central</li><li>Grand Londres</li><li>Guangdong</li><li>Massachusetts</li><li>Pays de la Loire</li><li>Québec</li><li>Rhénanie-Palatinat</li><li>Région capitale de Séoul</li></region><settlement><li>Jiangmen</li><li>Londres</li><li>Mayence</li><li>Montréal</li><li>Moscou</li><li>Nantes</li><li>Sha Tin</li><li>Séoul</li></settlement><orgName><li>Université McGill</li><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="Taïwan"><noRegion><name sortKey="Yang, James Chih Hsin" sort="Yang, James Chih Hsin" uniqKey="Yang J" first="James Chih-Hsin" last="Yang">James Chih-Hsin Yang</name></noRegion><name sortKey="Su, Wu Chou" sort="Su, Wu Chou" uniqKey="Su W" first="Wu-Chou" last="Su">Wu-Chou Su</name><name sortKey="Tsai, Chun Ming" sort="Tsai, Chun Ming" uniqKey="Tsai C" first="Chun-Ming" last="Tsai">Chun-Ming Tsai</name></country><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Wu, Yi Long" sort="Wu, Yi Long" uniqKey="Wu Y" first="Yi-Long" last="Wu">Yi-Long Wu</name></region><name sortKey="Feng, Jifeng" sort="Feng, Jifeng" uniqKey="Feng J" first="Jifeng" last="Feng">Jifeng Feng</name><name sortKey="Hu, Cheng Ping" sort="Hu, Cheng Ping" uniqKey="Hu C" first="Cheng-Ping" last="Hu">Cheng-Ping Hu</name><name sortKey="Huang, Yunchao" sort="Huang, Yunchao" uniqKey="Huang Y" first="Yunchao" last="Huang">Yunchao Huang</name><name sortKey="Lu, Shun" sort="Lu, Shun" uniqKey="Lu S" first="Shun" last="Lu">Shun Lu</name><name sortKey="Mok, Tony" sort="Mok, Tony" uniqKey="Mok T" first="Tony" last="Mok">Tony Mok</name><name sortKey="Zhou, Caicun" sort="Zhou, Caicun" uniqKey="Zhou C" first="Caicun" last="Zhou">Caicun Zhou</name></country><country name="Allemagne"><noRegion><name sortKey="Schuler, Martin" sort="Schuler, Martin" uniqKey="Schuler M" first="Martin" last="Schuler">Martin Schuler</name></noRegion><name sortKey="Sebastian, Martin" sort="Sebastian, Martin" uniqKey="Sebastian M" first="Martin" last="Sebastian">Martin Sebastian</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Popat, Sanjay" sort="Popat, Sanjay" uniqKey="Popat S" first="Sanjay" last="Popat">Sanjay Popat</name></region><name sortKey="Massey, Dan" sort="Massey, Dan" uniqKey="Massey D" first="Dan" last="Massey">Dan Massey</name><name sortKey="Shahidi, Mehdi" sort="Shahidi, Mehdi" uniqKey="Shahidi M" first="Mehdi" last="Shahidi">Mehdi Shahidi</name><name sortKey="Zazulina, Victoria" sort="Zazulina, Victoria" uniqKey="Zazulina V" first="Victoria" last="Zazulina">Victoria Zazulina</name></country><country name="Japon"><noRegion><name sortKey="Yamamoto, Nobuyuki" sort="Yamamoto, Nobuyuki" uniqKey="Yamamoto N" first="Nobuyuki" last="Yamamoto">Nobuyuki Yamamoto</name></noRegion><name sortKey="Kato, Terufumi" sort="Kato, Terufumi" uniqKey="Kato T" first="Terufumi" last="Kato">Terufumi Kato</name></country><country name="Australie"><noRegion><name sortKey="O Byrne, Kenneth" sort="O Byrne, Kenneth" uniqKey="O Byrne K" first="Kenneth" last="O'Byrne">Kenneth O'Byrne</name></noRegion><name sortKey="Boyer, Michael" sort="Boyer, Michael" uniqKey="Boyer M" first="Michael" last="Boyer">Michael Boyer</name></country><country name="Thaïlande"><noRegion><name sortKey="Geater, Sarayut L" sort="Geater, Sarayut L" uniqKey="Geater S" first="Sarayut L" last="Geater">Sarayut L. Geater</name></noRegion></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Lee, Kye Young" sort="Lee, Kye Young" uniqKey="Lee K" first="Kye Young" last="Lee">Kye Young Lee</name></region><name sortKey="Lee, Ki Hyeong" sort="Lee, Ki Hyeong" uniqKey="Lee K" first="Ki Hyeong" last="Lee">Ki Hyeong Lee</name></country><country name="Russie"><region name="District fédéral central"><name sortKey="Gorbunova, Vera" sort="Gorbunova, Vera" uniqKey="Gorbunova V" first="Vera" last="Gorbunova">Vera Gorbunova</name></region><name sortKey="Orlov, Sergey" sort="Orlov, Sergey" uniqKey="Orlov S" first="Sergey" last="Orlov">Sergey Orlov</name></country><country name="Canada"><region name="Québec"><name sortKey="Hirsh, Vera" sort="Hirsh, Vera" uniqKey="Hirsh V" first="Vera" last="Hirsh">Vera Hirsh</name></region></country><country name="France"><region name="Pays de la Loire"><name sortKey="Bennouna, Jaafar" sort="Bennouna, Jaafar" uniqKey="Bennouna J" first="Jaafar" last="Bennouna">Jaafar Bennouna</name></region></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. Sequist</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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